MITOCHONDRIAL REPLACEMENT THERAPY BETWEEN SCIENTIFIC DATA AND SHARIA PRINCIPLES
DOI:
https://doi.org/10.52747/aqujssis.6.1.527Keywords:
Mitochondria, Replacement, Jurisprudential ruling, Genetics, Sharia RulesAbstract
This study aims to clarify the Sharia ruling on mitochondrial replacement, a contemporary medical issue closely related to the objectives of Sharia and the preservation of lineage. The topic was selected due to the scarcity of jurisprudential studies addressing it and the need to shed light on its various dimensions. The study defines mitochondria, explains their functions and associated risks, outlines the technology and its methods, and examines the opinions of contemporary scholars, ultimately identifying the prevailing view. To achieve these aims, the study employs analytical, inductive, descriptive, and comparative methodologies to collect, analyze, and evaluate relevant information, with the goal of determining the most well-founded scholarly opinion. Mitochondria play a vital role in energy production, and their dysfunction can lead to serious health consequences. Although mitochondrial replacement may contribute to the birth of a healthy child, the majority of scholars prohibit it, arguing that its potential harms outweigh its benefits. This view is regarded as the stronger opinion based on a careful assessment of these risks. The study offers an integrated scientific and jurisprudential analysis, linking modern biomedical knowledge with Sharia principles. In doing so, it contributes to the enrichment of contemporary jurisprudential discourse and provides a solid foundation for deriving Sharia rulings on emerging medical technologies.
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Al-ʿAynī, Badr al-Dīn Maḥmūd. ʿUmdat al-qārī sharḥ Ṣaḥīḥ al-Bukhārī (Commentary on Ṣaḥīḥ al-Bukhārī). Beirut: Dār Iḥyāʾ al-Turāth al-ʿArabī, n.d.
Alberts, Bruce, et al. Essential Cell Biology. 4th ed. Garland Science, 2013.
Al-Bukhārī, Muḥammad ibn Ismāʿīl. Al-Jāmiʿ al-Ṣaḥīḥ (Ṣaḥīḥ al-Bukhārī) (The Authentic Collection of al-Bukhari). Cairo: al-Maṭbaʿa al-Amīriyya, n.d.
Al-Ḥamad, Ḥamad ibn ʿAbd Allāh. Sharḥ manẓūmat al-qawāʿid al-fiqhiyya li-al-Saʿdī (Commentary on al-Saʿdi’s Legal Maxims) [Audio lectures transcribed by Islamweb]. Available at: http://www.islamweb.net
Al-Ḥulwānī, Yāsīn Muḥammad. Al-jiyūfīzyāʾ al-bīʾiyya wa-al-fīzyāʾ al-ḥayawiyya (Environmental Geophysics and Biophysics). Desouk: Dār al-ʿIlm wa-al-Īmān, 2018.
ʻAlī, Aḥmad ʻAlī. "Al-mītukūndryā (al-mutqaddarāt) - al-tarkīb wa al-waẓīfah" (in Arabic). Ana ʻUṣaddiq al-ʻIlm, )retrieved on 20/1/2025), https://www.ibelieveinsci.com/%D8%A7%D9%84%D9%85%D9%8A% .
Al-Jaṣṣāṣ, Aḥmad ibn ʿAlī. Al-Fuṣūl fī al-uṣūl (Chapters on Legal Theory). Kuwait: Wizārat al-Awqāf al-Kuwaytiyya, 1994.
Al-Juwaynī, ʿAbd al-Malik ibn ʿAbd Allāh. Al-Burhān fī uṣūl al-fiqh (The Proof in Legal Theory). Beirut: Dār al-Kutub al-ʿIlmiyya, 1997.
Allam, Shawqi Ibrahim. “The Ruling on Mitochondrial Donation.” Dar Al-Ifta Al-Misriyyah, (2018), (retrieved on 12/3/2025), https://www.dar-alifta.org/ar/fatwa/details/14343/-.
Al-Nasāʾī, Aḥmad ibn Shuʿayb. Al-Sunan al-kubrā (The Major Sunan). Beirut: Muʾassasat al-Risāla, 2001.
Al-Qarnī, ʿAzīza bint Saʿīd. Al-istinsākh (dirāsa fiqhiyya) (Cloning: A Jurisprudential Study) [Published PhD dissertation]. Saudi Arabia: Jāmiʿat al-Imām Muḥammad ibn Saʿūd, 2003.
Al-Saʿdī, ʿAbd al-Raḥmān ibn Nāṣir. Bahjat qulūb al-abrār (Delight of the Hearts of the Righteous). Riyadh: Maktabat al-Rushd, 2002.
Al-Sadlān, Ṣāliḥ ibn Ghānim. Al-qawāʿid al-fiqhiyya al-kubrā wa-mā tafarraʿa ʿanhā (The Major Legal Maxims and Their Derivatives). Riyadh: Dār Balansiyya, 1996.
Al-Sanhūrī, Hishām ʿAbd Allāh. Al-wirātha wa-al-taqniyya al-ḥayawiyya fī al-asmāk (Genetics and Biotechnology in Fish). London: E-Kutub Ltd., 2018.
Al-Sarakhsī, Muḥammad ibn Aḥmad. Uṣūl al-Sarakhsī (Al-Sarakhsī’s Legal Theory). India: Lajnat Iḥyāʾ al-Maʿārif al-Nuʿmāniyya, n.d.
Al-Shāṭibī, Ibrāhīm ibn Mūsā. Al-Muwāfaqāt (The Reconciliations in Legal Theory). Dammam: Dār Ibn ʿAffān, 1997.
Al-Sijistānī, Abū Dāwūd Sulaymān ibn al-Ashʿath. Sunan Abī Dāwūd (The Sunan of Abu Dawud). Beirut: al-Maktaba al-ʿAṣriyya, n.d.
Al-Suyūṭī, Jalāl al-Dīn. Al-ashbāh wa-al-naẓāʾir (Analogies and Counterparts in Shāfiʿī Legal Maxims). Beirut: Dār al-Kutub al-ʿIlmiyya, 1983.
Al-Ṭabarī, Muḥammad ibn Jarīr. Jāmiʿ al-bayān ʿan taʾwīl āy al-Qurʾān (Comprehensive Commentary on Qur’anic Interpretation). Mecca: Dār al-Tarbiyya wa-al-Turāth, n.d.
Al-Tirmidhī, Muḥammad ibn ʿĪsā. Al-Jāmiʿ al-Kabīr (Sunan al-Tirmidhī) (The Major Collection of Hadith). Beirut: Dār al-Gharb al-Islāmī, 1996.
Al-Zahrānī, Jumʿa bint Ḥāmid. “Ḥukm al-tabarruʿ bi-al-mītūkūndriyā (dirāsa fiqhiyya)” (The Ruling on Mitochondrial Donation: A Jurisprudential Study). Majallat al-Qalam, 2012, 363–388.
Al-Zarkashī, Badr al-Dīn Muḥammad. Al-Manthūr fī al-qawāʿid al-fiqhiyya (The Scattered Principles of Legal Maxims). Kuwait: Wizārat al-Awqāf al-Kuwaytiyya, 1985.
Al-Zarqāʾ, Aḥmad ibn Muḥammad. Sharḥ al-qawāʿid al-fiqhiyya (Commentary on Legal Maxims). Damascus: Dār al-Qalam, 1989.
Belli, Antonouli, Nottola, Manuel, Sevastiani, Stefania Annarita. “Mitochondria in Mammalian Oocytes and Early Embryos (A Review on Morphological and Functional Studies)”. Euromediterranean Biomedical Journal 26 (2018): 114-117. DOI:10.3269/1970-5492.2018.13.26
Būzintiya, Mīrghanī; Bāḥāmid, Ankah Īmān; Muḥammad al-Wāthiq; Idrīs. “Naql al-mītūkūndriyā min manẓūr islāmī” (Mitochondrial Transfer from an Islamic Perspective). In Al-Muʾtamar al-Dawlī al-Awwal: al-ʿUlūm al-Sharʿiyya, Taḥaddiyāt al-Wāqiʿ wa-Āfāq al-Mustaqbal, 2018, 1101–1112.
Chan, David. “Mitochondria: Dynamic Organelles in Disease, Aging, and Development”. cell press journal 125, no.7 (2006): 1241-1252, DOI:10.1016/j.cell.2006.06.01.
Craven, Lyndsey,et al. “Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease”. Nature 465, no.7294 (2010): 82-85, DOI:10.1038/nature08958
Ellinas, Frost, Herodotos, Elizabeth Ann. “Mitochondrial Disorders (A Review of Anesthetic Considerations)”. Middle East Journal of Anesthesiology 21, no.2 (2011): 42-235.
Espley, Bloomin, Catherine, and Robert. Genes and Education (The Impact of Genes on Education and Academic Achievement). Windsor, United Kingdom: Hindawi Foundation, 2017.
Farnezim, Hana Carolina Moreira, et al. “Three-parent babies: Mitochondrial replacement therapies, JBRA Assisted Reproduction”. Journ¬¬al Brasileiro de Reprodução Assistida 24, no.2 (2020): 189-196. DOI: 10.5935/1518-0557.20190086
Gharati, Erez. “Mitochondria – The Powerhouse of the Cell.” Science Repository, (218), (retrieved on 20/1/2025), https://davidson.weizmann.ac.il/ar/online/maagarmada/
Ḥabannaka, ʿAbd al-Raḥmān al-Maydānī. Kawāshif zuyūf fī al-madhāhib al-fikriyya al-muʿāṣira (Exposing Fallacies in Contemporary Ideological Schools). Damascus: Dār al-Qalam, 1991.
Hilāl, Hudā. “Ḥukm naql al-mītūkūndriyā… ruʾya fiqhiyya muʿāṣira” (The Ruling on Mitochondrial Transfer: A Contemporary Jurisprudential Perspective). Journal of Islamic Ethics, 2023, 204–224.
Ibn al-Qayyim, Muḥammad ibn Abī Bakr. Iʿlām al-muwaqqiʿīn ʿan rabb al-ʿālamīn (Informing the Signatories on Behalf of the Lord of the Worlds). Beirut: Dār al-Kutub al-ʿIlmiyya, 1991.
Ibn ʿĀshūr, Muḥammad al-Ṭāhir. Maqāṣid al-sharīʿa al-islāmiyya (Objectives of Islamic Law). Qatar: Wizārat al-Awqāf, 2004.
Ibn Nujaym, Zayn al-Dīn. Al-ashbāh wa-al-naẓāʾir ʿalā madhhab Abī Ḥanīfa (Legal Analogies in the Ḥanafī School). Beirut: Dār al-Kutub al-ʿIlmiyya, 1999.
Ibn Qudāma, ʿAbd Allāh ibn Aḥmad. Al-Mughnī (The Sufficient). Cairo: Maktabat al-Qāhira, 1969.
Ibn Taymiyya, Aḥmad ibn ʿAbd al-Ḥalīm. Rafʿ al-malām ʿan al-aʾimma al-aʿlām (Removal of Blame from the Eminent Imams). Riyadh: al-Riʾāsa al-ʿĀmma li-Idārāt al-Buḥūth al-ʿIlmiyya, 1983.
Ibrāhīm, Iyād Aḥmad. Al-handasa al-warāthiyya bayna al-muʿṭayāt al-ʿilmiyya wa-al-ḍawābiṭ al-sharʿiyya (Genetic Engineering between Scientific Data and Sharia Regulations) [Published PhD dissertation]. Jordan: Kulliyyat al-Sharīʿa, al-Jāmiʿa al-Urduniyya, 2001.
Isbili, Blūmīn; Kāthrīn; Rūbart. Al-jīnāt wa-al-taʿlīm (taʾthīr al-jīnāt ʿalā al-taʿlīm wa-al-taḥṣīl al-dirāsī) (Genes and Education: The Impact of Genes on Education and Academic Achievement). Windsor, UK: Muʾassasat Hindāwī, 2017.
Islamic Fiqh Academy. “A Resolution on Test-Tube Babies.” Resolutions and Recommendations of the International Islamic Fiqh Academy affiliated with the Organization of Islamic Cooperation, International Islamic Fiqh Academy, (1986), Resolution No. 16, (retrieved on 14/3/2025), https://iifa-aifi.org/ar/1661.html
Liao, Xiaoyu, et al. “Significant decrease of maternal mitochondria carryover using optimized spindle-chromosomal complex transfer”. PLOS Biology 21, no.10 (2023): 1-18. DOI:10.1371/journal.pbio.3002313
Majmaʿ al-Lugha al-ʿArabiyya. Majmūʿat al-muṣṭalaḥāt al-ʿilmiyya wa-al-fanniyya (Collection of Scientific and Technical Terminology). Cairo: n.p., 2002.
Mālik ibn Anas. Al-Muwaṭṭaʾ (The Muwatta). Beirut: Dār Iḥyāʾ al-Turāth al-ʿArabī, 1985.
Muslim ibn al-Ḥajjāj. Ṣaḥīḥ Muslim (The Authentic Collection of Muslim). Cairo: Maṭbaʿat ʿĪsā al-Bābī al-Ḥalabī, 1955.
Shvaikovsky, Maria. “What are the Differences between Pronuclear Transfer and Spindle Transfer”. IFG, (retrieved on 21/2/2025), https://ifg-ivf.com/blog/what-are-the-differences
Tatay, Andreum, Aznar, Lucía Gómez, José M. Hernández, Justo. “Mitochondrial Modification Techniques and Ethical Issues”. Journal of Clinical Medicine 6, no.3 (2017): 1-16. DOI: 10.3390/jcm6030025
Wolf, Mitalipov, Mitalipov, Don Wolf, Nargiz Mitalipov, Shoukhrat Mitalipov. “Mitochondrial Replacement Therapy in Reproductive Medicine, Trends in Molecular”. cell press journal 21, no.2 (2015): 68-76. DOI: 10.1016/j.molmed.2014.12.001
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